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LT - Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs
EN - Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs

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Bibliographic data
Indications of the International Patent Classification (IPC)
(51) INT.CL. C12N 15/11
C07H 21/04
A61K 31/7088
European patent
(11) Number of the document 1819365
(13) Kind of document T
(96) European patent application number 05853546.9
Date of filing the European patent application 2005-12-09
(97) Date of publication of the European application 2007-08-22
(45) Date of publication and mention of the grant of the patent 2014-07-02
(46) Date of publication of the claims translation
PCT application
(86) Number PCT/US2005/044662
Date 2005-12-09
PCT application publication
(87) Number WO 2006/063252
Date 2006-06-15
Priority applications
(30) Number Date Country code
634849 P 2004-12-09 US
Inventors
(72)
DE FOUGEROLLES, Antonin, US
Grantee
(73) Alnylam Pharmaceuticals Inc., 300 Third Street, Cambridge, MA 02142, US
Hartmann, Gunther, Noestrasse 19, 81479 München, DE
Hornung, Veit, Martinshofstr. 16, 82049 Pullach, DE
Endres, Stefan, Osterwaldstrasse 58, 80805 München, DE
Title
(54) Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs
  Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs