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LT - A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with sorafenib, sunitinib or erlotinib
EN - A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with sorafenib, sunitinib or erlotinib

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Bibliographic data
Indications of the International Patent Classification (IPC)
(51) INT.CL. A61K 31/517
A61K 31/4745
A61K 31/4412
A61K 31/404
A61K 45/06
A61P 35/00
European patent
(11) Number of the document 2396003
(13) Kind of document T
(96) European patent application number 10704696.3
Date of filing the European patent application 2010-02-11
(97) Date of publication of the European application 2011-12-21
(45) Date of publication and mention of the grant of the patent 2013-04-17
(46) Date of publication of the claims translation
PCT application
(86) Number PCT/US2010/023893
Date 2010-02-11
PCT application publication
(87) Number WO 2010/093789
Date 2010-08-19
Priority applications
(30) Number Date Country code
152138 P 2009-02-12 US
170471 P 2009-04-17 US
Inventors
(72)
CHAN, Thomas C.K., US
FRANCE, Dennis S., US
ISHII, Kenichi, JP
PUCCI, Paolo, US
Grantee
(73) Kyowa Hakko Kirin Co., Ltd., 1-6-1, Ohtemachi, Chiyoda-ku, Tokyo 100-8185, JP
ArQule, Inc., 19 Presidential Way, Woburn, MA 01801, US
Title
(54) A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with sorafenib, sunitinib or erlotinib
  A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with sorafenib, sunitinib or erlotinib