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LT - CODON-OPTIMIZED FACTOR VIII VARIANTS AND SYNTHETIC LIVER-SPECIFIC PROMOTER

EN - CODON-OPTIMIZED FACTOR VIII VARIANTS AND SYNTHETIC LIVER-SPECIFIC PROMOTER

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Bibliographic data

Indications of the International Patent Classification (IPC)
(51)	INT.CL.	A61K 38/37
		C07K 14/755
		C12N 15/85

European patent
(11)	Number of the document	2451474
(13)	Kind of document	T
(96)	European patent application number	10731905.5
	Date of filing the European patent application	2010-07-08
(97)	Date of publication of the European application	2012-05-16
(45)	Date of publication and mention of the grant of the patent	2013-12-18
(46)	Date of publication of the claims translation

PCT application
(86)	Number	PCT/US2010/041378
	Date	2010-07-08

PCT application publication
(87)	Number	WO 2011/005968
	Date	2011-01-13

Priority applications
(30)	Number	Date	Country code
	0911870	2009-07-08	GB

Inventors
(72)	NATHWANI, Amit, GB WARD, Natalie, GB THRASHER, Adrian, GB TUDDENHAM, Edward, GB MCVEY, John, GB GRAY, John, US DAVIDOFF, Andrew, US

Grantee
(73)	UCL Business PLC, The Network Building 97 Tottenham Court Road, London Greater London W1T 4TP, GB Thrombosis Research Institute, Emmanuel Kaye Building 1 Manresa Road Chelsea, Greater London SW3 6LR, GB ST. JUDE CHILDREN`S RESEARCH HOSPITAL, 262 Danny Thomas Place, Memphis, TN 38105-3678, US

Title
(54)	CODON-OPTIMIZED FACTOR VIII VARIANTS AND SYNTHETIC LIVER-SPECIFIC PROMOTER
	CODON-OPTIMIZED FACTOR VIII VARIANTS AND SYNTHETIC LIVER-SPECIFIC PROMOTER