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LT - DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE
EN - DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE

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Bibliographic data
Indications of the International Patent Classification (IPC)
(51) INT.CL. C12N 15/113
C12N 15/11
C12P 21/00
European patent
(11) Number of the document 2576580
(13) Kind of document T
(96) European patent application number 11787435.4
Date of filing the European patent application 2011-05-26
(97) Date of publication of the European application 2013-04-10
(45) Date of publication and mention of the grant of the patent 2016-09-14
(46) Date of publication of the claims translation
PCT application
(86) Number PCT/US2011/038191
Date 2011-05-26
PCT application publication
(87) Number WO 2011/150241
Date 2011-12-01
Priority applications
(30) Number Date Country code
349727 P 2010-05-28 US
Inventors
(72)
ZHOU, Meixia, US
SNEDECOR, Bradley, Richard, US
NG, Chi Kin, Domingos, US
SHEN, Amy, US
Grantee
(73) F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, CH
Title
(54) DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE
  DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE
Last update date 2021-04-30