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LT - 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure
EN - 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure

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Bibliographic data
Indications of the International Patent Classification (IPC)
(51) INT.CL. C07D 413/14
C07D 403/04
C07D 417/14
A61K 31/4155
A61P 43/00
European patent
(11) Number of the document 2797915
(13) Kind of document T
(96) European patent application number 12812498.9
Date of filing the European patent application 2012-12-26
(97) Date of publication of the European application 2014-11-05
(45) Date of publication and mention of the grant of the patent 2016-07-13
(46) Date of publication of the claims translation
PCT application
(86) Number PCT/US2012/071654
Date 2012-12-26
PCT application publication
(87) Number WO 2013/101830
Date 2013-07-04
Priority applications
(30) Number Date Country code
201161580439 P 2011-12-27 US
201261654580 P 2012-06-01 US
Inventors
(72)
KIM, Charles, US
NAKAI, Takashi, US
MOORE, Joel, US
PERL, Nicholas, Robert, US
IM, G-yoon, Jamie, US
BARDEN, Timothy, Claude, US
IYENGAR, Rajesh, R., US
ZIMMER, Daniel, P., US
FRETZEN, Angelika, US
RENHOWE, Paul, Allan, US
Grantee
(73) Ironwood Pharmaceuticals, Inc., 301 Binney Street, 2nd Floor, Cambridge, MA 02142, US
Title
(54) 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure
  2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure