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LT - PREPARATION OF 3-[(S)-7-BROMO-2-(2-HYDROXY-PROPYLAMINO)-5-PYRIDIN-2-YL-3H-1,4-BENZODIAZEPIN-3-YL]PROPIONIC ACID METHYL ESTER WITH A WORK-UP METHOD WITHOUT AMMONIUM CONTAINING SOLUTIONS
EN - PREPARATION OF 3-[(S)-7-BROMO-2-(2-HYDROXY-PROPYLAMINO)-5-PYRIDIN-2-YL-3H-1,4-BENZODIAZEPIN-3-YL]PROPIONIC ACID METHYL ESTER WITH A WORK-UP METHOD WITHOUT AMMONIUM CONTAINING SOLUTIONS

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Bibliographic data
Indications of the International Patent Classification (IPC)
(51) INT.CL. C07D 401/04
B01J 31/02
C07D 487/04
A61K 31/5517
A61P 25/02
A61P 25/20
C07B 61/00
European patent
(11) Number of the document 2966069
(13) Kind of document T
(96) European patent application number 14759551.6
Date of filing the European patent application 2014-03-03
(97) Date of publication of the European application 2016-01-13
(45) Date of publication and mention of the grant of the patent 2020-01-08
(46) Date of publication of the claims translation
PCT application
(86) Number PCT/JP2014/055329
Date 2014-03-03
PCT application publication
(87) Number WO 2014/136730
Date 2014-09-12
Priority applications
(30) Number Date Country code
2013041492 2013-03-04 JP
Inventors
(72)
KAWAKAMI, Yuji, JP
MURASE, Tatsushi, JP
TANAKA, Daisuke, JP
YOSHIYAMA, Hideyuki, JP
KUWABE, Shinitsu, JP
Grantee
(73) Paion UK Limited, Chivers Way, Histon, Cambridge CB24 9ZR, GB
Title
(54) PREPARATION OF 3-[(S)-7-BROMO-2-(2-HYDROXY-PROPYLAMINO)-5-PYRIDIN-2-YL-3H-1,4-BENZODIAZEPIN-3-YL]PROPIONIC ACID METHYL ESTER WITH A WORK-UP METHOD WITHOUT AMMONIUM CONTAINING SOLUTIONS
  PREPARATION OF 3-[(S)-7-BROMO-2-(2-HYDROXY-PROPYLAMINO)-5-PYRIDIN-2-YL-3H-1,4-BENZODIAZEPIN-3-YL]PROPIONIC ACID METHYL ESTER WITH A WORK-UP METHOD WITHOUT AMMONIUM CONTAINING SOLUTIONS