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Legal status
Patent not validated
| (51) | INT.CL. | C12N 15/63 | (2006.01) |
| C12N 9/22 | (2013.01) | ||
| C12N 9/22 | (2006.01) | ||
| A61P 43/00 | (2018.01) | ||
| C12N 15/10 | (2006.01) | ||
| C12N 15/102 | (2013.01) | ||
| C12N2310/20 | (2017.05) | ||
| C12N 15/113 | (2013.01) | ||
| C12N 15/90 | (2013.01) | ||
| C12N 15/63 | (2013.01) |
| (11) | Number of the document | 3011030 |
| (13) | Kind of document | T |
| (96) | European patent application number | 14734709.0 |
| Date of filing the European patent application | 2014-06-10 | |
| (97) | Date of publication of the European application | 2016-04-27 |
| (45) | Date of publication and mention of the grant of the patent | 2023-11-08 |
| (46) | Date of publication of the claims translation |
| (86) | Number | PCT/US2014/041803 |
| Date | 2014-06-10 |
| (87) | Number | WO 2014/204725 |
| Date | 2014-12-24 |
| (30) | Number | Date | Country code |
| 201361836123 P | 2013-06-17 | US | |
| 201361847537 P | 2013-07-17 | US | |
| 201361862355 P | 2013-08-05 | US | |
| 201361871301 P | 2013-08-28 | US | |
| 201361915383 P | 2013-12-12 | US | |
| PCT/US2013/074667 | 2013-12-12 | WO |
| (72) |
ZHANG, Feng , US
HSU, Patrick , US
LIN, Chie-yu , US
RAN, Fei , US
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| (73) |
The Broad Institute, Inc. ,
415 Main Street, Cambridge, MA 02142,
US
Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, MA 02142, US President and Fellows of Harvard College , 17 Quincy Street, Cambridge, MA 02138, US |
| (54) | OPTIMIZED CRISPR-CAS DOUBLE NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION |
| OPTIMIZED CRISPR-CAS DOUBLE NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION |