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| (51) | INT.CL. | C12N 9/22 | (2006.01) |
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| (11) | Number of the document | 3365357 |
| (13) | Kind of document | T |
| (96) | European patent application number | 16794114.5 |
| Date of filing the European patent application | 2016-10-22 | |
| (97) | Date of publication of the European application | 2018-08-29 |
| (45) | Date of publication and mention of the grant of the patent | 2024-02-14 |
| (46) | Date of publication of the claims translation |
| (86) | Number | PCT/US2016/058345 |
| Date | 2016-10-22 |
| (87) | Number | WO 2017/070633 |
| Date | 2017-04-27 |
| (30) | Number | Date | Country code |
| 201562245828 P | 2015-10-23 | US | |
| 201662279346 P | 2016-01-15 | US | |
| 201662311763 P | 2016-03-22 | US | |
| 201662322178 P | 2016-04-13 | US | |
| 201662357332 P | 2016-06-30 | US | |
| 201662357352 P | 2016-06-30 | US | |
| 201662370700 P | 2016-08-03 | US | |
| 201662398490 P | 2016-09-22 | US | |
| 201662408686 P | 2016-10-14 | US |
| (72) |
LIU, David, R. , US
HU, Johnny, Hao , US
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| (73) |
President and Fellows of Harvard College ,
17 Quincy Street, Cambridge, MA 02138,
US
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| (54) | EVOLVED CAS9 PROTEINS FOR GENE EDITING |
| EVOLVED CAS9 PROTEINS FOR GENE EDITING |