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| (51) | INT.CL. | C12N 5/079 | (2010.01) | 
| A61P 27/02 | (2018.01) | ||
| A61K 9/70 | (2006.01) | ||
| A61P 43/00 | (2018.01) | ||
| A61K 31/4409 | (2006.01) | ||
| C12N 5/0621 | (2013.01) | ||
| C12N2500/38 | (2013.01) | ||
| A61K 31/4439 | (2006.01) | ||
| A61K 31/4709 | (2006.01) | ||
| C12N2501/11 | (2013.01) | ||
| A61K 31/519 | (2006.01) | ||
| A61K 31/519 | (2013.01) | ||
| A61K 31/713 | (2006.01) | ||
| A61K 31/4439 | (2013.01) | ||
| A61K 35/30 | (2015.01) | ||
| C12N2501/155 | (2013.01) | ||
| A61L 27/00 | (2006.01) | ||
| A61K 31/4709 | (2013.01) | ||
| A61P 27/02 | (2006.01) | ||
| C12N2501/727 | (2013.01) | ||
| A61K 31/713 | (2013.01) | ||
| C12N2500/14 | (2013.01) | ||
| A61K 35/30 | (2013.01) | ||
| C12N2501/15 | (2013.01) | ||
| A61K 31/4409 | (2013.01) | ||
| A01N 1/0226 | (2013.01) | ||
| C12N2501/90 | (2013.01) | 
| (11) | Number of the document | 3553169 | 
| (13) | Kind of document | T | 
| (96) | European patent application number | 19172604.1 | 
| Date of filing the European patent application | 2012-12-27 | |
| (97) | Date of publication of the European application | 2019-10-16 | 
| (45) | Date of publication and mention of the grant of the patent | 2021-11-03 | 
| (46) | Date of publication of the claims translation | 
| (30) | Number | Date | Country code | 
| 2011289666 | 2011-12-28 | JP | |
| 2012030969 | 2012-02-15 | JP | |
| 2012151340 | 2012-07-05 | JP | 
| (72) | 
                    
                    
                    
                    
                    Kinoshita, Shigeru , JP  
                    
                    
                    
                    
                    Koizumi, Noriko , JP  
                    
                    
                    
                    
                    Okumura, Naoki , JP  | 
| (73) | Kyoto Prefectural Public University Corporation ,
                465, Kajii-cho 
Kawaramachi-dori, Hirokoji-agaru 
Kamigyo-ku, Kyoto-shi, Kyoto 602-8566,
                JP ActualEyes Inc. , 1-D-egg 314 Jizodani Kodo, Kyotanabe-city, Kyoto, JP CorneaGen, Inc. , 1200 6th Ave., Ste. 300, Seattle, WA 98101, US | 
| (54) | NORMALIZATION OF CULTURE OF CORNEAL ENDOTHELIAL CELLS | 
| NORMALIZATION OF CULTURE OF CORNEAL ENDOTHELIAL CELLS |