LT - Combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo- phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide and the Akt inhibitor N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]et
EN - Combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo- phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide and the Akt inhibitor N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]et
Legal status
Patent not validated
Bibliographic data
Indications of the International Patent Classification (IPC)
| (51) |
INT.CL. |
A01N 43/54 |
|
|
|
A61K 31/415 |
|
|
|
A61K 31/505 |
|
European patent
| (11) |
Number of the document |
2480085 |
| (13) |
Kind of document |
T |
| (96) |
European patent application number |
10819438.2 |
|
Date of filing the European patent application |
2010-09-23 |
| (97) |
Date of publication of the European application |
2012-08-01 |
| (45) |
Date of publication and mention of the grant of the patent |
2014-11-12
|
| (46) |
Date of publication of the claims translation |
|
PCT application
| (86) |
Number |
PCT/US2010/049952 |
|
Date |
2010-09-23 |
PCT application publication
| (87) |
Number |
WO 2011/038085 |
|
Date |
2011-03-31 |
Priority applications
| (30) |
Number |
Date |
Country code |
|
245027 P |
2009-09-23
|
US |
Inventors
| (72) |
DUMBLE, Melissa, US
GILMER, Tona, US
KUMAR, Rakesh, US
LEBOWITZ, Peter, F., US
MORRIS, Shannon, Renae, US
LAQUERRE, Sylvie, US
|
Grantee
| (73) |
GlaxoSmithKline LLC,
Corporation Service Company 2711 Centreville Road Suite 400, Wilmington, Delaware 19808,
US
|
Title
| (54) |
Combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo- phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide and the Akt inhibitor N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]et |
| |
Combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo- phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide and the Akt inhibitor N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]et |
