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LT - PHARMACEUTICALLY ACCEPTABLE SALT OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
EN - PHARMACEUTICALLY ACCEPTABLE SALT OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF

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Bibliographic data
Indications of the International Patent Classification (IPC)
(51) INT.CL. C07D 401/14
A61K 31/4709
A61P 35/00
European patent
(11) Number of the document 2684877
(13) Kind of document T
(96) European patent application number 12757831.8
Date of filing the European patent application 2012-02-10
(97) Date of publication of the European application 2014-01-15
(45) Date of publication and mention of the grant of the patent 2016-10-19
(46) Date of publication of the claims translation
PCT application
(86) Number PCT/CN2012/071015
Date 2012-02-10
PCT application publication
(87) Number WO 2012/122865
Date 2012-09-20
Priority applications
(30) Number Date Country code
201110062359 2011-03-11 CN
Inventors
(72)
LI, Xin, CN
WANG, Bin, CN
Grantee
(73) Shanghai Hengrui Pharmaceutical Co. Ltd., 279 Wenjing Road, Minhang District Shanghai 200245, CN
Jiangsu Hengrui Medicine Co. Ltd., No. 7 Kunlunshan Road Economic and Technological Development Zone Lianyungang, Jiangsu 222047, CN
Title
(54) PHARMACEUTICALLY ACCEPTABLE SALT OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
  PHARMACEUTICALLY ACCEPTABLE SALT OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF