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LT - 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS
EN - 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS

Legal status

Patent not validated

Bibliographic data
Indications of the International Patent Classification (IPC)
(51) INT.CL. C07D 241/18 (2006.01)
C07D 403/12 (2013.01)
C07D 241/20 (2006.01)
C07D 403/04 (2013.01)
C07D 403/12 (2006.01)
C07D 241/18 (2013.01)
C07D 403/04 (2006.01)
C07D 241/20 (2013.01)
A61K 31/497 (2006.01)
A61P 35/02 (2018.01)
A61K 31/4985 (2006.01)
A61P 35/04 (2018.01)
A61P 35/00 (2006.01)
C07D 401/04 (2013.01)
C07D 477/26 (2013.01)
C07D 487/04 (2013.01)
European patent
(11) Number of the document 3484856
(13) Kind of document T
(96) European patent application number 17742609.5
Date of filing the European patent application 2017-07-11
(97) Date of publication of the European application 2019-05-22
(45) Date of publication and mention of the grant of the patent 2023-11-15
(46) Date of publication of the claims translation
PCT application
(86) Number PCT/US2017/041577
Date 2017-07-11
PCT application publication
(87) Number WO 2018/013597
Date 2018-01-18
Priority applications
(30) Number Date Country code
201662361249 P 2016-07-12 US
201762449523 P 2017-01-23 US
Inventors
(72)
JOGALEKAR, Ashutosh , US
WON, Walter , US
KOLTUN, Elena S. , US
GILL, Adrian , US
MELLEM, Kevin , US
AAY, Naing , US
BUCKL, Andreas , US
SEMKO, Christopher , US
KISS, Gert , US
Grantee
(73) Revolution Medicines, Inc. , 700 Saginaw Drive, Redwood City, CA 94063, US
Title
(54) 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS
  2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS